Dichloromethane → 1-Chloro-2-methylpropyl 2,2-dimethylpropanoate
반응식
[CH3:1][C:2]([CH3:7])(C)[C:3]([Cl:5])=[O:4].[CH:8](=[O:12])[CH:9]([CH3:11])[CH3:10].[CH2:13](Cl)Cl>>[CH3:10][C:9]([CH3:13])([CH3:11])[C:8]([O:4][CH:3]([Cl:5])[CH:2]([CH3:7])[CH3:1])=[O:12]참가 물질
4
실험 절차
To freshly fused zinc chloride (27.3 mg) and trimethylacetylchloride (5.11 ml, 41.5 mmol) in methylene chloride(10 ml) at 10° C. was added isobutyraldehyde (freshly distilled) (3.77 ml, 41.5 mmol) dropwise, maintaining the temperature at <25° C. Once the addition was complete, the reaction was stirred for one hour at room temperature. The reaction mixture was then washed with 20% NaOAc, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give the title A compound (3.25 g) as a clear liquid.
후처리
- distillationfreshly distilled) (3.77 ml, 41.5 mmol) dropwise
- temperaturemaintaining the temperature at <25° C
- additionOnce the addition
- washThe reaction mixture was then washed with 20% NaOAc
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-1ba397f515244fa79781508aae6583cf
- 출처 데이터셋
- uspto-grants-1994_12
- 특허 번호
- US05374615
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