Phthalic Anhydride → HCID 16654924, 화합물

HRID 1492922노트

반응식

HRID 1492922 반응식
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.Cl.[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH2:19].C(N(CC)CC)C>C1(C)C=CC=CC=1>[Cl:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6]

참가 물질

5

반응물 3

HCID 6811Phthalic AnhydrideHCID 8471TriethylamineHCID 189498945-Chloropentan-1-aminato(4-)--hydrogen chlorido(4-) (1/1)

생성물 1

HCID 16654924HCID 16654924, 화합물수율 72.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 20.6 g (0.139 mole) of phthalic anhydride, 20 g (0.126 mole) of 5-chloropentylamine hydrochloride and 17.6 ml (0.126 mole) of triethylamine in 250 ml of toluene was heated to 130° C. for 4 hours. The obtained mixture was evaporated to dryness. The residue was taken up into 200 ml of water and extracted with ethyl acetate. The phases were separated and the organic phase was dried over sodium sulfate and evaporated to dryness. From the crude product, 23 g of the title product were obtained as an oil having the following characteristics:

후처리

  1. customThe obtained mixture was evaporated to dryness
  2. extractionextracted with ethyl acetate
  3. customThe phases were separated
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-8116affbaa734cef96d8a0e07d2b2bf2
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05376673

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