Hydrochloric Acid → HCID 178493552, 화합물

HRID 1493091노트

반응식

HRID 1493091 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH2:12])[N:4]=1.[ClH:13].[N:14]#[C:15][NH2:16]>C(O)C>[ClH:13].[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH:12][C:15]([NH2:16])=[NH:14])[N:4]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 9864CyanamideHCID 144790742-Hydrazinyl-4,6-dimethoxypyrimidine

생성물 1

HCID 178493552HCID 178493552, 화합물수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 17.0 g (0.1 mol) of 4,6-dimethoxy-2-hydrazino-pyrimidine, 8.3 ml of concentrated hydrochloric acid, 4.2 g (0.1 mol) of cyanamide and 100 ml of ethanol is boiled to reflux for 18 hours. The mixture is then evaporated, the residue is crystallized using diethyl ether, and the crystalline product is isolated by filtering off with suction. 22.9 g (92% of theory) of (4,6-dimethoxy-pyrimidin-2-yl-amino)-guanidine hydrochloride of melting point 214° C. are obtained.

후처리

  1. temperatureto reflux for 18 hours
  2. customThe mixture is then evaporated
  3. customthe residue is crystallized
  4. customthe crystalline product is isolated
  5. filtrationby filtering off with suction

출처 및 근거

ORD 기록
ord-7001074c92aa4970aee78a943d85a89a
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021082

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