Sodium Hydroxide → 3-(Pyrrolidine-1-carbonyl)thiomorpholine
반응식
[OH-].[Na+].Cl.[N:4]1([C:9]([CH:11]2[CH2:16][S:15][CH2:14][CH2:13][NH:12]2)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]1>C(Cl)Cl>[N:4]1([C:9]([CH:11]2[CH2:16][S:15][CH2:14][CH2:13][NH:12]2)=[O:10])[CH2:5][CH2:6][CH2:7][CH2:8]1참가 물질
4
실험 절차
A 1N aqueous sodium hydroxide solution (12.5 ml) was added to a mixture of 2.47 g of 3-(pyrrolidine-1-carbonyl)thiomorpholine monohydrochloride and 20 ml of methylene chloride. The organic layer was extracted and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to yield 1.75 g (83%) of 3-(pyrrolidine-1-carbonyl)thiomorpholine
후처리
- extractionThe organic layer was extracted
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-1a6464a159d4459ba7820972dddd3f38
- 출처 데이터셋
- uspto-grants-1991_06
- 특허 번호
- US05021413
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