2-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene → 2-(4-Chlorobenzylamino)-5-fluoroaniline

HRID 1493320노트

반응식

HRID 1493320 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[N+:17]([O-])=O)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[NH2:17])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 149529762-(4-Chlorophenylmethylamino)-5-fluoronitrobenzene

생성물 1

HCID 149529912-(4-Chlorobenzylamino)-5-fluoroaniline수율 91.6%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

41.7 g of 2-(4-chlorophenylmethylamino)-5-fluoronitrobenzene, prepared in Example 1, are dissolved in 1 l of tetrahydrofuran and hydrogenated at ordinary temperature and pressure in the presence of 5 g of Raney nickel. When the theoretical amount of hydrogen has been absorbed, the catalyst is filtered off and the solvent is evaporated off under vacuum to give 34.1 g of 2-(4-chlorophenylmethylamino)-5-fluoroaniline in the form of crystals melting at 99° C.

후처리

  1. customWhen the theoretical amount of hydrogen has been absorbed
  2. filtrationthe catalyst is filtered off
  3. customthe solvent is evaporated off under vacuum

출처 및 근거

ORD 기록
ord-01ce8d5bbdfa444c8d9f507886eb50f2
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021443

반응 노트

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