Ethyl 4-bromobutyrate → Ethyl 4-[(1H-benzimidazol-2-yl)sulfanyl]butanoate

HRID 1493323노트

반응식

HRID 1493323 반응식
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[Na].Br[CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[NH:6][C:2]=1[S:1][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

5

반응물 3

HCID 76300Ethyl 4-bromobutyrateHCID 5360545SodiumHCID 178527775HCID 178527775, 화합물

생성물 1

HCID 12624992Ethyl 4-[(1H-benzimidazol-2-yl)sulfanyl]butanoate수율 97.5%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

50 g of 2-mercaptobenzimidazole are dissolved in 300 ml of ethanol, and a solution of 7.65 g of sodium in 150 ml of ethanol is added at room temperature, with stirring. The mixture is stirred for a few minutes at room temperature and 64.3 g of ethyl 4-bromobutyrate are added rapidly. The reaction mixture is refluxed for 6 hours and then cooled. The solvents are evaporated off to dryness under vacuum, the residue is taken up with water and the crystals obtained are filtered off, washed with water and then with ether and dried to give 85 g of ethyl 4-(benzimidazol-2-yl)mercaptobutanoate in the form of crystals melting at 70°-72° C.

후처리

  1. stirringThe mixture is stirred for a few minutes at room temperature
  2. temperatureThe reaction mixture is refluxed for 6 hours
  3. temperaturecooled
  4. customThe solvents are evaporated off to dryness under vacuum
  5. customthe crystals obtained
  6. filtrationare filtered off
  7. washwashed with water
  8. dry with materialwith ether and dried

출처 및 근거

ORD 기록
ord-1793e07a61884481b46ffcfba89a7fa2
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021443

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