Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl- → 2-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenone

HRID 1493426

반응식

HRID 1493426 반응식
[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH2:17][CH:18]2[O:20][CH2:19]2)[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH2:21]([NH:25][CH:26]1[CH2:31][C:30]([CH3:33])([CH3:32])[N:29]([O:34][CH:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)[C:28]([CH3:42])([CH3:41])[CH2:27]1)[CH2:22][CH2:23][CH3:24]>C(O)C>[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH2:17][CH:18]([OH:20])[CH2:19][N:25]([CH2:21][CH2:22][CH2:23][CH3:24])[CH:26]2[CH2:31][C:30]([CH3:32])([CH3:33])[N:29]([O:34][CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([CH3:42])([CH3:41])[CH2:27]2)[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:5]

참가 물질

4

반응물 2

HCID 13118721Methanone, [2-hydroxy-4-(oxiranylmethoxy)phenyl]phenyl-HCID 211821294-Butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine

생성물 1

HCID 198313562-Hydroxy-4-{3-[N-butyl-N-(1-cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-yl)amino]-2-hydroxypropoxy}benzophenone수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4.0 g (14.8 g mmol) of 2-hydroxy-4-(2,3-epoxypropoxy)benzophenone, 6.9 g (22.2 mmol) of 4-butylamino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine, and 40 ml of ethanol is heated at reflux for 4 hours. Ethanol is evaporated, and the residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate) to afford 7.9 g (92% yield) of the title compound, a yellow oil.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 4 hours
  3. customEthanol is evaporated
  4. customthe residue is purified by flash chromatography on silica gel (4:1 heptane: ethyl acetate)

출처 및 근거

ORD 기록
ord-a570d021a0e74516a4da3eca9e2dd342
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021478

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