1-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine → HCID 14986895, 화합물

HRID 1493595노트

반응식

HRID 1493595 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:16]=[CH:17][C:18]([N+:21]([O-])=O)=[N:19][CH:20]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>C(OCC)(=O)C.[Pt]>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[CH:20][N:19]=1

참가 물질

4

반응물 1

HCID 48776161-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine

생성물 1

HCID 14986895HCID 14986895, 화합물

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8857Ethyl Acetate용매

실험 절차

A suspension of the product of part (i) (0.65 g, 2.0 mmole) in ethyl acetate (30 ml) was hydrogenated over 5% platinum on carbon (25 mg) at 45 p.s.i. (310 kPa) and at 50° for 12 hours, followed by 45 hours at room temperature. The resulting mixture was filtered to remove the catalyst, concentrated under reduced pressure and the residue triturated with ether to yield the desired product, m.p. 182°-188° (0.28 g, 50%), which was used without further purification.

후처리

  1. waitfollowed by 45 hours at room temperature
  2. filtrationThe resulting mixture was filtered
  3. customto remove the catalyst
  4. concentrationconcentrated under reduced pressure
  5. customthe residue triturated with ether

출처 및 근거

ORD 기록
ord-4236b47c11214086b5e1a549ff117784
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05023258

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