4-Acetylpyridine → HCID 3285123, 화합물

HRID 1493706노트

반응식

HRID 1493706 반응식
[Cl:1][C:2]1[CH:13]=[C:12]([Cl:14])[C:11]([Cl:15])=[CH:10][C:3]=1[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7].[C:16]([C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)(=O)[CH3:17].O1CCOCC1>C(O)(=O)C>[N:22]1[CH:23]=[CH:24][C:19]([C:16](=[N:9][NH:8][C:6](=[O:7])[CH2:5][O:4][C:3]2[CH:10]=[C:11]([Cl:15])[C:12]([Cl:14])=[CH:13][C:2]=2[Cl:1])[CH3:17])=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 142824-AcetylpyridineHCID 312751,4-DioxaneHCID 456735Acetic acid, (2,4,5-trichlorophenoxy)-, hydrazide

생성물 1

HCID 3285123HCID 3285123, 화합물수율 83.7%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 5.39 gm (0.02 mole) of 2,4,5-trichlorophenoxyacetic acid hydrazide, 2.42 gm (0.02 mole) of 4-acetylpyridine, 125 ml of dioxane and 2 ml of acetic acid is refluxed 4 hr. The hot solution is filtered. The filtrate is diluted with water until cloud point. The mixture is cooled to room temperature and then chilled in the refrigerator. The product is collected to yield 6.24 gm (83%) of the title compound having a melting point of 227.4° C. (decomp).

후처리

  1. filtrationThe hot solution is filtered
  2. additionThe filtrate is diluted with water until cloud point
  3. temperaturechilled in the refrigerator
  4. customThe product is collected

출처 및 근거

ORD 기록
ord-c50cfacfe5ef49c2b6d67a2df633c776
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05023334

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