Thionyl Chloride → 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride

HRID 1493878

반응식

HRID 1493878 반응식
[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5](O)=[O:6].S(Cl)([Cl:12])=O>>[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5]([Cl:12])=[O:6]

참가 물질

3

반응물 2

HCID 24386Thionyl Chloride2회HCID 146952292,2-Difluoro-1-methylcyclopropane-1-carboxylic acid

생성물 1

HCID 146952322,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride수율 77%

실험 절차

A mixture of 250 g (1.8 mol) of 2,2-difluoro-1-methylcyclopropanecarboxylic acid and 700 ml of thionyl chloride is slowly heated in a distillation apparatus, during which process excess thionyl chloride distills over first and the desired product later. In this manner, 215 g (77% of theory) of 2,2-difluoro-1-methyl-cyclopropanecarbonyl chloride are obtained in form of a liquid of boiling point 121°-122° C. ##STR56##

후처리

  1. distillationdistills over first and the desired product later

출처 및 근거

ORD 기록
ord-7b2d3e43e06f4fceb5f1a24097227d99
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05025030

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