Hydrochloric Acid → 10-(5-aminomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

HRID 1494813노트

반응식

HRID 1494813 반응식
C([NH:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][N:10]([C:15]1[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[CH:21]([CH3:25])[CH2:22][O:23][C:24]=1[C:19]=34)[CH2:9]2)(=O)C.Cl.O.O1C2C=CC(C(O)=O)=CC=2C=CN1>C(O)C>[NH2:4][CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[CH2:11][N:10]([C:15]1[C:16]([F:33])=[CH:17][C:18]3[C:28](=[O:29])[C:27]([C:30]([OH:32])=[O:31])=[CH:26][N:20]4[CH:21]([CH3:25])[CH2:22][O:23][C:24]=1[C:19]=34)[CH2:9]2

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 21624997Benzoxazine-6-carboxylic acidHCID 6792243210-(5-acetamidomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

생성물 1

HCID 5424461510-(5-aminomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de][1,4]-benzoxazine-6-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

315 mg of 10-(5-acetamidomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6carboxylic acid was added to a mixed solution of 12 ml of concentrated HCl, 2.5 ml of water, and 5 ml of ethanol, and the mixture was heated under reflux for 15 hours. After the mixture was concentrated under reduced pressure, the residue was recrystallized from ethanol to obtain 170 mg of 10-(5-aminomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]1,4]-benzoxazine-6-carboxylic acid.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 15 hours
  3. concentrationAfter the mixture was concentrated under reduced pressure
  4. customthe residue was recrystallized from ethanol
  5. customto obtain 170 mg of 10-(5-aminomethyl-2-isoindolinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-

출처 및 근거

ORD 기록
ord-cda002c69e774e60bcf6526a3b4298ac
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05026856

반응 노트

불러오는 중…