Hydrochloric Acid → 7-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

HRID 1494822노트

반응식

HRID 1494822 반응식
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([CH2:27][NH:28]C(=O)C)[CH:24]=4)[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([CH:32]2[CH2:34][CH2:33]2)[CH:7]=1)=[O:5])C.[ClH:35]>C(O)C>[ClH:35].[NH2:28][CH2:27][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[CH2:19][N:18]([C:11]1[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[CH:32]3[CH2:34][CH2:33]3)=[CH:13][C:12]=1[F:17])[CH2:26]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 572711897-(5-Acetamidomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester

생성물 1

HCID 679223597-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

80 mg of 7-(5-acetamidomethyl-2-isoindolinyl)-1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester was dissolved in a mixture of 10 ml of 10% hydrochloric acid and 10 ml of ethanol. The mixture was heated under reflux for 24 hours. The precipitates deposited were collected by filtration and washed with water and ethanol in this order to obtain 68 mg of 7-(5-aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. filtrationThe precipitates deposited were collected by filtration
  4. washwashed with water and ethanol in this order

출처 및 근거

ORD 기록
ord-2ec7002a7a8d43619d56c391fd13a0db
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05026856

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