홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Carbonate → 2-Benzyloxycarbonyl-4-(tertbutyloxycarbonylaminomethyl)isoindoline

HRID 1494851
노트
인쇄 미리보기

반응식

HRID 1494851 반응식
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:9]1)C1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+].Cl[C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34]>C(Cl)(Cl)Cl>[CH2:36]([O:35][C:33]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:9]1)=[O:34])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 10387Benzyl chloroformateHCID 19828499N-BOC-(2-Benzylisoindolin-4-yl)methanamine

생성물 1

HCID 198284932-Benzyloxycarbonyl-4-(tertbutyloxycarbonylaminomethyl)isoindoline수율 91.1%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3.38 g of 2-benzyl-4-(tertbutyloxycarbonylaminomethyl)isoindoline was dissolved in 10 ml of chloroform and 1.27 g of sodium carbonate was added to it. To this solution was added dropwise 2.04 g of benzyl chloroformate under ice-cooling and stirring, and the mixture was stirred for 2 hours at room temperature. Insoluble materials were removed by filtration and the filtrate was concentrated. Recrystallization from ether gave 3.48 g of 2-benzyloxycarbonyl-4-(tertbutyloxycarbonylaminomethyl)isoindoline.

후처리

  1. temperaturecooling
  2. stirringthe mixture was stirred for 2 hours at room temperature
  3. customInsoluble materials were removed by filtration
  4. concentrationthe filtrate was concentrated
  5. customRecrystallization from ether

출처 및 근거

ORD 기록
ord-f8c0b66c1a854b0a89db90027aabecf8
출처 데이터셋
uspto-grants-1991_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05026856

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트