2,4-Dichloropyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde

반응식

[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH:9]([C:11]1[CH:12]=[CH:13][C:14]([O:20][CH3:21])=[C:15](B(O)O)[CH:16]=1)=[O:10]>>[Cl:1][C:2]1[N:7]=[C:6]([C:13]2[CH:12]=[C:11]([CH:16]=[CH:15][C:14]=2[O:20][CH3:21])[CH:9]=[O:10])[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 775312,4-Dichloropyrimidine

HCID 27343675-Formyl-2-methoxyphenylboronic acid

생성물 1

HCID 249018763-(2-Chloropyrimidin-4-yl)-4-methoxybenzaldehyde수율 70%

실험 절차

2,4 dichloropyrimidine and 5-formyl-2-methoxyphenylboronic acid was coupled following procedure A. The yield was 70%. LC-MS showed the product was >95% pure and had the expected M+H+ of 249. 1H NMR (Varian 300 MHz, MeOD-d6, shifts relative to the solvent peak at 3.33 ppm) δ 9.9 (s, 1H) 8.7 (d, 1H) 8.4 (s, 1H) 8.0 (d, 2H) 7.4 (d, 1H) 3.9 (s, 3H).

출처 및 근거

ORD 기록: ord-4ce789c572b7461498d343a62c43931b
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732444B2

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