Hydrochloric Acid → Methyl 2-fluoro-4-methylbenzoate
반응식
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:12]O.Cl>>[CH3:12][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([CH3:11])=[CH:10][C:2]=1[F:1]참가 물질
4
실험 절차
2-Fluoro-4-methylbenzoic acid (30.0 g, 195 mmol) was dissolved in MeOH (600 mL, 10 mol), and 12 M HCl (3.2 mL, 39 mmol) was added. The mixture was heated to reflux and stirred for 48 hours, then cooled and concentrated. The recovered material was dried in vacuo for 24 hours to obtain Intermediate (6a) as a white solid that was used without further purification.
후처리
- temperatureThe mixture was heated
- temperatureto reflux
- temperaturecooled
- concentrationconcentrated
- customThe recovered material was dried in vacuo for 24 hours
출처 및 근거
- ORD 기록
- ord-9e89a7e663e1430d9fbe4830be07feca
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09198899B2
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