Ammonia → 7-Bromoquinolin-5-ol

HRID 1496844노트

반응식

HRID 1496844 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([O:12]C)[CH:3]=1.Br.N>O>[OH:12][C:4]1[CH:3]=[C:2]([Br:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 712378127-Bromo-5-methoxyquinoline

생성물 1

HCID 1362166197-Bromoquinolin-5-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.5 g (0.0064 mol) of 7-bromo-5-methoxy-quinoline were refluxed with 48% HBr (30 ml) for 20h. After cooling to room temperature reaction mixture was poured into 100 ml of water and basified with saturated ammonia solution. Product was filtered off, washed with water and dried at 50° C. in vacuo. Yield of 7-bromo-5-hydroxy-quinoline was 600 mg (41%).

후처리

  1. customreaction mixture
  2. filtrationProduct was filtered off
  3. washwashed with water
  4. customdried at 50° C. in vacuo

출처 및 근거

ORD 기록
ord-02bdefb191324228bee808c9a6938667
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199937B2

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