Methyl iodide → 7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

HRID 1496853노트

반응식

HRID 1496853 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:13]I>CN(C=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[N:7]([CH3:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodide2회HCID 1355556127-Bromo-3,4-dihydroquinazolin-4-one

생성물 1

HCID 585745147-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
25 °C

실험 절차

400 mg 7-Bromoquinazolin-4(3H)-one was dissolved in DMF and 720 mg of CsCO3 and 130 μL of methyliodide were added and the mixture stirred for 3 h at 25° C. Additional 50 μL methyliodide were added and stirred overnight at 25° C. The mixture was filtered off and the mother liquor diluted with DCM and extracted with water. The solvent was removed to yield 490 mg of 7-bromo-3-methylquinazolin-4(3H)-one as solid.

후처리

  1. stirringstirred overnight at 25° C
  2. filtrationThe mixture was filtered off
  3. additionthe mother liquor diluted with DCM
  4. extractionextracted with water
  5. customThe solvent was removed

출처 및 근거

ORD 기록
ord-168871d7a6094b93b910d797bb03ca6c
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199937B2

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