참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-(2-acetyl-4-bromophenyl)acetamide | HCID 459291 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6-Bromo-2,4-dimethylquinazoline | HCID 58329327 | 23.4% |
반응 단계
415 mg N-(2-acetyl-4-bromophenyl)acetamide and 0.624 g of ammonium acetate was dissolved in 5 mL of glacial acetic acid and heated for 2 days at 100° C. The solvent was removed and the residue suspended in water and extracted with DCM. The organic phase was concentrated and purified via FCC (25 g SiO2, DCM:MeOH 100:0→70:30) to yield 90 mg of 6-bromo-2,4-dimethylquinazoline as oil. Analysis: HPLC-MS: Rt=1.26 min (method V003—003), M+H=237/239.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09199937B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_12 |
|---|
| ORD ID | ord-be0150cd47cd4957a9fe924c07924e25 |
|---|
| 출처 메모 | uspto-grants-2015_12 |
|---|
