反应详情

温度

100 °C

415 mg N-(2-acetyl-4-bromophenyl)acetamide and 0.624 g of ammonium acetate was dissolved in 5 mL of glacial acetic acid and heated for 2 days at 100° C. The solvent was removed and the residue suspended in water and extracted with DCM. The organic phase was concentrated and purified via FCC (25 g SiO2, DCM:MeOH 100:0→70:30) to yield 90 mg of 6-bromo-2,4-dimethylquinazoline as oil. Analysis: HPLC-MS: Rt=1.26 min (method V003—003), M+H=237/239.

1. customThe solvent was removed
2. extractionextracted with DCM
3. concentrationThe organic phase was concentrated
4. custompurified via FCC (25 g SiO2, DCM:MeOH 100:0→70:30)