Iodoethane → 2-Ethoxy-4-fluoronitrobenzene

HRID 1496944

반응식

HRID 1496944 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([OH:8])[CH:7]=1.[CH2:12](I)[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([O:8][CH2:12][CH3:13])[CH:7]=1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 99375-Fluoro-2-nitrophenolHCID 11430Potassium Carbonate

생성물 1

HCID 129181532-Ethoxy-4-fluoronitrobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-fluoro-2-nitrophenol (300 mg), ethyliodide (0.50 mL) and potassium carbonate (500 mg) were dissolved in dimethylformamide (DMF, 3 mL), and reacted at 50° C. overnight. The dimethylformamide of the reaction mixture was concentrated under reduced pressure, added with water and the organic layer was extracted with ethyl acetate. The organic layer was washed with brine, and the water was removed with sodium sulfate, and the solvent was removed under reduced pressure. The thus obtained compound was used in the subsequent reaction without further purification.

후처리

  1. customreacted at 50° C. overnight
  2. concentrationThe dimethylformamide of the reaction mixture was concentrated under reduced pressure
  3. additionadded with water
  4. extractionthe organic layer was extracted with ethyl acetate
  5. washThe organic layer was washed with brine
  6. customthe water was removed with sodium sulfate
  7. customthe solvent was removed under reduced pressure
  8. customThe thus obtained compound was used in the subsequent reaction without further purification

출처 및 근거

ORD 기록
ord-e9fa60d31de64c67a1bbb8cfa6cdd244
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199944B2

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