Sodium Hydroxide → 6-Chloro-2-isopropoxy-4-phenyl-quinoline-3-carboxylic acid

HRID 1497062노트

반응식

HRID 1497062 반응식
C([O:3][C:4]([C:6]1[C:7]([O:23][CH:24]([CH3:26])[CH3:25])=[N:8][C:9]2[C:14]([C:15]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:13][C:12]([Cl:22])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[Cl:22][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:23][CH:24]([CH3:26])[CH3:25])[C:6]([C:4]([OH:5])=[O:3])=[C:15]2[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866829336-Chloro-2-isopropoxy-4-phenyl-quinoline-3-carboxylic acid ethyl ester

생성물 1

HCID 715562916-Chloro-2-isopropoxy-4-phenyl-quinoline-3-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The title compound was prepared in analogy to example 6 step B from a mixture of 6-chloro-2-isopropoxy-4-phenyl-quinoline-3-carboxylic acid ethyl ester and 1N NaOH in ethanol. Off white solid (17.2 mg, 47%). LC-MS: 342 (M+H)+.

출처 및 근거

ORD 기록
ord-4b0c1a69d92d43afb9ab2316d2a0591a
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199938B2

반응 노트

불러오는 중…