Thionyl Chloride → 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole

HRID 1497412

반응식

HRID 1497412 반응식
S(Cl)([Cl:3])=O.[F:5][C:6]([F:15])([F:14])[C:7]1[S:8][CH:9]=[C:10]([CH2:12]O)[N:11]=1>>[Cl:3][CH2:12][C:10]1[N:11]=[C:7]([C:6]([F:15])([F:14])[F:5])[S:8][CH:9]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

생성물 1

HCID 177504144-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole수율 60.7%

실험 절차

Thionyl chloride (4.89 g) was added to [2-(trifluoromethyl)thiazol-4-yl]methanol (512 mg) at room temperature, and the mixture was stirred for 3 hr. The reaction mixture was concentrated to give the title compound (342 mg).

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-c6f91f438ef24adf9d0a6d6db989878b
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09199963B2

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