1,3-Propanediamine → N1-(6-Bromo-3-iodoimidazo[1,2-a]pyrazin-8-yl)propane-1,3-diamine
반응식
[CH2:1]([NH2:5])[CH2:2][CH2:3][NH2:4].[Br:6][C:7]1[N:8]=[C:9](S(C)(=O)=O)[C:10]2[N:11]([C:13]([I:16])=[CH:14][N:15]=2)[CH:12]=1>CN(C)C=O>[Br:6][C:7]1[N:8]=[C:9]([NH:4][CH2:3][CH2:2][CH2:1][NH2:5])[C:10]2[N:11]([C:13]([I:16])=[CH:14][N:15]=2)[CH:12]=1참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
To a solution of 1.26 mL propane-1,3-diamine in 8 mL 2.0 g N,N-dimethylformamide was added a solution of (4.98 mmol) 6-bromo-3-iodo-8-(methylsulfonyl)imidazo[1,2-a]pyrazine which was prepared according to intermediate example 60c in 20 mL N,N-dimethylformamide at 40° C. during 1.5 hours. The mixture was stirred at 40° C. for additional 1.5 hours. The solvent was removed and the residue was purified by chromatography to give 1.52 g (77%) of the title compound.