Hydrochloric Acid → (4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone

HRID 1498844노트

반응식

HRID 1498844 반응식
[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:28]=[CH:27][C:5]([C:6]([C:8]2[CH:9]=[N:10][C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 118023371HCID 118023371, 화합물

생성물 1

HCID 118022709(4-Fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone수율 90.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate (8.2 g, 21.24 mmol) in dioxane (50 mL) was added HCl in dioxane (4 M, 20 mL). The reaction mixture was stirred at RT overnight. LCMS showed the reaction was completed. The mixture was concentrated to get the title compound as a light yellow solid (5.5 g, 90%). MS (ES+) C15H15FN4O requires: 286. found: 287 [M+H]+.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-b35c0e9897dc4767b5efa24714bbb4cb
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09200002B2

반응 노트

불러오는 중…