Iodoethane → Ethyl 2-isonicotinoylthiophene-3-carboxylate

HRID 1498885노트

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HRID 1498885 반응식
[C:1]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([OH:16])=[O:15])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.C([O-])([O-])=O.[Cs+].[Cs+].[CH3:23][CH2:24]I>CC#N>[C:1]([C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH2:23][CH3:24])=[O:15])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 10796Cesium carbonateHCID 866831162-Isonicotinoylthiophene-3-carboxylic acid

생성물 1

HCID 86683117Ethyl 2-isonicotinoylthiophene-3-carboxylate수율 85.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
30 °C

실험 절차

To a solution of 2-isonicotinoylthiophene-3-carboxylic acid (2.2 g, 9.4 mmol) from example 2.1 and Cs2CO3 (6.2 g, 18.9 mmol) in CH3CN (500 mL) was added CH3CH2I (2.9 g, 18.9 mmol) dropwise. The mixture was stirred at 30° C. for 48 h. The mixture was filtered and concentrated to give the title compound (2.1 g, 85.5% yield) as yellow oil. LC-MS (Method A): m/z 340 (M+H)+, Rt: 0.81 min.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b52c70d465e6462fb1f79944b0275241
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09200005B2

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