Cesium carbonate → (S)-2-benzyl 3-ethyl 8-(5-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyridazin-3-yl)-2,8-diazaspiro[4.5]decane-2,3-dicarboxylate

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Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([O:8][C@H:9]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[N:21]2[CH:25]=[CH:24][C:23]([CH3:26])=[N:22]2)[C:10]([F:13])([F:12])[F:11])[CH:7]=1.ClC1C=C(O[C@H](C2C=CC(Cl)=CC=2N2C=CC(C)=N2)C(F)(F)F)N=NC=1.[CH2:53]1[C:57]2([CH2:62][CH2:61][NH:60][CH2:59][CH2:58]2)[CH2:56][CH:55]([C:63]([O:65][CH2:66][CH3:67])=[O:64])[N:54]1[C:68]([O:70][CH2:71][C:72]1[CH:77]=[CH:76][CH:75]=[CH:74][CH:73]=1)=[O:69].C([O-])([O-])=O.[Cs+].[Cs+].C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C@@H:9]([O:8][C:6]2[CH:7]=[C:2]([N:60]3[CH2:59][CH2:58][C:57]4([CH2:53][N:54]([C:68]([O:70][CH2:71][C:72]5[CH:73]=[CH:74][CH:75]=[CH:76][CH:77]=5)=[O:69])[C@H:55]([C:63]([O:65][CH2:66][CH3:67])=[O:64])[CH2:56]4)[CH2:62][CH2:61]3)[N:3]=[N:4][CH:5]=2)[C:10]([F:12])([F:11])[F:13])=[C:15]([N:21]2[CH:25]=[CH:24][C:23]([CH3:26])=[N:22]2)[CH:16]=1