N-bromobutanimide → HCID 86718002, 화합물

HRID 1500463노트

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HRID 1500463 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.C1C(=O)N([Br:19])C(=O)C1>CN(C=O)C>[Br:19][C:10]1[C:6]2[CH2:7][CH2:8][O:9][C:5]=2[C:4]([NH2:11])=[CH:3][C:2]=1[CH3:1]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amine

생성물 1

HCID 86718002HCID 86718002, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
0 °C

실험 절차

To a mixture of 5-methyl-2,3-dihydrobenzofuran-7-amine (1d) (1.0 g, 6.7 mmol) in DMF (21 mL) at 0° C., was added NBS (1.19 g, 6.7 mmol), it was stirred at 0° C., for 15 min. The mixture was extracted with EtOAc (150 mL), washed with saturated NaHSO3 (50 mL), water, brine, dried and concentrated. The residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (20:1) to give the title compound (1e) as a yellow solid. MS-ESI (m/z): 228 (M+1)+.

후처리

  1. extractionThe mixture was extracted with EtOAc (150 mL)
  2. washwashed with saturated NaHSO3 (50 mL), water, brine
  3. customdried
  4. concentrationconcentrated
  5. customThe residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (20:1)

출처 및 근거

ORD 기록
ord-a29238825bde4c5998fa3ff4d3ceb847
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206166B2

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