Triphenylphosphine → HCID 86718007, 화합물

HRID 1500469노트

반응식

HRID 1500469 반응식
O[C@@H:2]([CH3:12])[CH2:3][C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=1[OH:11].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:12][C@@H:2]1[CH2:3][C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[O:11]1

참가 물질

5

반응물 3

HCID 11776TriphenylphosphineHCID 5363146Diisopropyl azodicarboxylateHCID 86718006HCID 86718006, 화합물

생성물 1

HCID 86718007HCID 86718007, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture of (S)-2-(2-hydroxypropyl)-4-methylphenol (3c) (1.6 g, 8.4 mmol) and triphenylphosphine (2.7 g, 10 mmol) in THF (60 mL) was added DIAD at ambient temperature. It was concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1) to give the title compound (3d).

후처리

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by column chromatography on silica gel eluting with hexanes/EtOAc (10:1)

출처 및 근거

ORD 기록
ord-2e574ee400bf45f883d79ad70b89b075
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206166B2

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