Hydrochloric Acid → 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

HRID 1500551노트

반응식

HRID 1500551 반응식
[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2>CO>[ClH:1].[S:2]1[CH:6]=[CH:5][C:4]2[C:7]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:8][CH:9]=[CH:10][C:3]1=2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 210731871-(Benzo[b]thiophen-4-yl)piperazine

생성물 1

HCID 574825411-(1-Benzothiophen-4-yl)piperazine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3.7 ml of concentrated hydrochloric acid was added to a methanol solution of 9.5 g of 1-benzo[b]thiophen-4-yl-piperazine, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue and precipitated crystals were filtrated and recrystallized from methanol and 1-benzo[b]thiophen-4-yl-piperazine hydrochloride was obtained as colorless needle-like crystals.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. additionEthyl acetate was added to the residue
  3. customprecipitated crystals
  4. filtrationwere filtrated
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-e23b946abf22472783ad19580957631e
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206167B2

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