Lithium hydroxide, monohydrate → lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1500632

반응식

HRID 1500632 반응식
C[O:2][C:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)=[O:4].O.[OH-].[Li+:14]>CO.O>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C:3]([O-:4])=[O:2])[CH2:9][O:8]1.[Li+:14]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

생성물 1

HCID 67153178lithium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate수율 96.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a solution of (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester (5.0 g, 31.25 mmol) in MeOH (32.0 mL) at room temperature was added a solution of lithium hydroxide monohydrate (1.31 g, 31.25 mmol) in water (10.0 mL). The resulting mixture was stirred for thirty min before it was concentrated. The resulting white solid was further dried under vacuum to give the title compound (4.59 g).

후처리

  1. concentrationwas concentrated
  2. customThe resulting white solid was further dried under vacuum

출처 및 근거

ORD 기록
ord-f650585eca2441ecb9ab575c02d1a92b
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206172B2

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