2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile → HCID 178429083, 화합물

HRID 1501216노트

반응식

HRID 1501216 반응식
[NH2:1][C:2]1[O:3][C:4]([CH3:11])=[CH:5][C:6](=[O:10])[C:7]=1[C:8]#[N:9]>Cl>[OH:3][C:2]1[N:1]=[C:4]([CH3:11])[CH:5]=[C:6]([OH:10])[C:7]=1[C:8]#[N:9]

참가 물질

3

반응물 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

생성물 1

HCID 178429083HCID 178429083, 화합물수율 83.3%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A suspension of 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile (6.0 g, 40 mmol) in 10% HCl (60 mL) was heated under reflux for 4 hours. The precipitate was collected by filtration and washed with water, and then recrystallized from methanol to give 2,4-dihydroxy-6-methylnicotinonitrile (5.0 g, 80%) as a brown solid. 1H NMR (300 MHz, CD3OD): δ 12.44-12.46 (m, 1H), 11.69 (s, 1H), 5.85 (s, 1H), 2.15 (s, 3H).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-81eef2658e0b419f90d3024435e43db7
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09206128B2

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