Hydrochloric Acid → 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([O:15]C)=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1.[OH-].[K+].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1참가 물질
5
실험 절차
A mixture of intermediate (5) (0.25 mol) and KOH (1 mol) in water (650 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled, acidified with HCl and the resulting precipitate was filtered off, washed with water, and dried, yielding 48 g of 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid (intermediate 6).
후처리
- temperaturerefluxed for 2 hours
- temperatureThe reaction mixture was cooled
- filtrationthe resulting precipitate was filtered off
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-24184dbec21a4aa9b4efa62e8f9234f6
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732464B2
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