Sodium Hydroxide → 2-(2',3'-Dichloro[1,1'-biphenyl]-3-yl)propanedioic acid

HRID 1502594노트

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HRID 1502594 반응식
C([O:3][C:4](=[O:25])[CH:5]([C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=2[Cl:24])[CH:14]=[CH:15][CH:16]=1)[C:6]([O:8]CC)=[O:7])C.[OH-].[Na+]>>[Cl:24][C:18]1[C:19]([Cl:23])=[CH:20][CH:21]=[CH:22][C:17]=1[C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH:5]([C:4]([OH:25])=[O:3])[C:6]([OH:8])=[O:7])[CH:12]=1

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3

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HCID 14798Sodium HydroxideHCID 669733992-(2',3'-Dichloro-[1,1'-biphenyl]-3-yl)propanedioic acid 1,3-diethyl ester2회

생성물 1

HCID 669736132-(2',3'-Dichloro[1,1'-biphenyl]-3-yl)propanedioic acid

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온도
70 °C

실험 절차

2-(2′,3′-Dichloro-[1,1′-biphenyl]-3-yl)propanedioic acid 1,3-diethyl ester (i.e. the product of Step B, 0.30 g, 0.79 mmol) was added to 2% aqueous sodium hydroxide (5 mL), and the reaction mixture was heated at 70° C. for 20 min. The reaction mixture was cooled, quenched with 6 N aqueous hydrochloric acid, and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over sodium sulfate, and concentrated under reduced pressure to yield the title compound (0.20 g).

후처리

  1. temperatureThe reaction mixture was cooled
  2. customquenched with 6 N aqueous hydrochloric acid
  3. extractionextracted with ethyl acetate
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8f42987e55ae46eba333ecf240453a94
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09210932B2

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