Sodium Hydroxide → 2-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid

HRID 1503095노트

반응식

HRID 1503095 반응식
[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([O:20]CC)=[O:19])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([OH:20])=[O:19])=[CH:6][CH:5]=2)[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 54764233Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate

생성물 1

HCID 680010602-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate (0.286 mmol) and aqueous sodium hydroxide solution (1 M, 2 mmol) in methanol is stirred at 60° C. for 12 hours. The reaction mixture is then concentrated, acidified, filtered and the isolated solid purified by to chromatography.

후처리

  1. concentrationThe reaction mixture is then concentrated
  2. filtrationfiltered
  3. customthe isolated solid purified by to chromatography

출처 및 근거

ORD 기록
ord-9ffd21a163cb48e6b4e0da7568852800
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212135B2

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