Glyoxylic Acid → HCID 86680931, 화합물

HRID 1503177노트

반응식

HRID 1503177 반응식
[S:1]1[CH2:5][CH:4]([C:6]([OH:8])=[O:7])[NH:3][CH:2]1[C:9]([OH:11])=O.N[C@H:13](C(O)=O)CS.C(O)(=O)C=O.S(Cl)([Cl:26])=O.[CH3:28][OH:29]>>[ClH:26].[CH3:28][O:29][C:9]([CH:2]1[NH:3][CH:4]([C:6]([O:8][CH3:13])=[O:7])[CH2:5][S:1]1)=[O:11]

참가 물질

6

반응물 5

HCID 760Glyoxylic AcidHCID 887MethanolHCID 5862L-(+)-CysteineHCID 24386Thionyl ChlorideHCID 72150Tidiacic

생성물 1

HCID 86680931HCID 86680931, 화합물수율 94%

실험 절차

Thiazolidine-2,4-dicarboxylic acid (1.00 g, 5.67 mmol) synthesized from L-cysteine and glyoxylic acid (aqueous solution) were added to a methanol solution (15 ml) of thionyl chloride (22.6 mmol), and the mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated, and to the residue was added ether. The crystals were collected by filtration, washed with ether, and dried under reduced pressure to give thiazolidine-2,4-dicarboxylic acid 2,4-dimethyl ester hydrochloride as crystals (1.29 g, 94.0%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue was added ether
  3. filtrationThe crystals were collected by filtration
  4. washwashed with ether
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-81f6adf7ed254f95881f9fe114afebb9
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09212154B2

반응 노트

불러오는 중…