글리옥실산

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature supports the wearing of contact lenses in industrial environments, as part of a program to protect the eye against chemical compounds and minerals causing eye irritation. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases contact lenses should not be worn.

SUCCINIMIDE HAS A HYPOOXALURIC EFFECT IN NORMAL RATS & IN RATS WITH GLYOXYLIC ACID-INDUCED LITHIASIS.

IN PRESENCE OF NADH, HYDROXYPYRUVATE STIMULATED THE OXIDN OF GLYOXYLATE TO OXALATE & DECR THE REDN OF GLYOXYLATE IN VITRO PREPARATIONS FROM NORMAL HUMAN ERYTHROCYTES & LEUKOCYTES, RAT LIVER, & WITH PURIFIED LACTATE DEHYDROGENASE FROM BEEF HEART.

INJECTIONS OF OXALOACETATE TOGETHER WITH LETHAL DOSE OF GLYOXYLATE PROTECTED RAT FROM DEATH, BUT PRODUCED A SEVERE INHIBITION OF BOTH MITOCHONDRIAL AND CYTOPLASMIC ACONITATE HYDRATASE & ISOCITRATE DEHYDROGENASE. OXIDN OF CITRATE EITHER ADDED OR FORMED FROM PYRUVATE & FUMARATE IN MITOCHONDRIA WAS STRONGLY INHIBITED. DATA SUGGEST THAT THE INHIBITION OF ACONITATE HYDRATASE & ISOCITRATE (NADP+) DEHYDROGENASE WAS DUE TO OXALOMALATE FORMED IN VIVO WITH THE SAME MECHANISM OF CONDENSATION OF GLYOXYLATE PLUS OXALOACETATE.

It has been proposed that administration of non-nitrogenous precursors to glycine is necessary to realize the full potential of benzoate metabolism as a pathway for disposal of waste nitrogen during ammonia intoxication. However, when glyoxylate, a keto acid precursor to glycine, was administered with benzoate 1 hr prior to a challenge of ammonia, protection against ammonia toxicity was less successful than with benzoate alone. At the cellular and subcellular levels, glyoxylate and benzoate each inhibited the urea cycle in isolated hepatocytes and pyruvate carboxylase in isolated mitochondria. The action of each drug was associated with depletion of aspartate content in isolated hepatocytes and reduction of pyruvate-dependent incorporation of carbon dioxide into aspartate in assays with isolated mitochondria. Depression of aspartate regeneration by inhibition of pyruvate carboxylase is a likely mechanism for impairment of urea cycle activity by both drugs. In whole animals, inhibition of pyruvate carboxylase may contribute to benzoate toxicity and the adverse influence of glyoxylate on benzoate therapy.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that glyoxylic acid is expected to have very high mobility in soil(SRC). The pKa of glyoxylic acid is 3.3(3), which indicates that this compound will exist primarily as an anion in moist soil surfaces and anions are expected to have very high mobility in soils(SRC). Volatilization of glyoxylic acid from moist soil surfaces is not expected to be an important fate process(SRC) since the anion will not volatilize and the neutral species has an estimated Henry's Law constant of 3X10-9 atm-cu m/mole at 25 °C(SRC), using a fragment constant estimation method(4). Glyoxylic acid may volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 1 mm Hg at 25 °C(5). By analogy to other aliphatic acids(6-8), biodegradation is expected to be an important degradation process for glyoxylic acid in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that glyoxylic acid is not expected to adsorb to suspended solids and sediment(SRC). The pKa of glyoxylic acid is 3.3(3), which indicates that this compound will exist primarily as an anion in water(SRC). Volatilization of glyoxylic acid from water surfaces is not expected to be an important fate process(SRC) since the anion will not volatilize and the neutral species has an estimated Henry's Law constant of 3X10-9 atm-cu m/mole at 25 °C(SRC), using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.4(SRC) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Direct photolysis in sunlit surface waters may also be an important fate pathway since glyoxylic acid undergoes rapid direct photolysis in ambient air(7). By analogy to other aliphatic acids(8-10), biodegradation is expected to be an important degradation process for glyoxylic acid in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), glyoxylic acid, which has an estimated vapor pressure of 1 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase glyoxylic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 29 hours(SRC), calculated from its rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Glyoxylic acid also occurs in the dissolved-phase in rainwater, clouds, fog and mist(4,5). Vapor-phase glyoxylic acid undergoes rapid direct photolysis in the ambient atmosphere and has a daytime persistence that is not expected to exceed a few hours(4).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for glyoxylic acid can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that glyoxylic acid is expected to have very high mobility in soil. The pKa of glyoxylic acid is 3.3(3), which indicates that this compound will exist primarily as an anion in moist soil surfaces and anions are expected to have very high mobility in soils(SRC).

Piridoxilate is given in cases of angina pectoris or arteritis. It is an intramolecular association of glyoxylic hemiacetal salts of pyridoxine. Glyoxylate has a membranous protective action; pyridoxine is used for the theoretical purpose of preventing oxidation of glyoxylic acid to oxalic acid. Twelve patients were observed with an active calcium oxalate lithiasis who had been taking piridoxilate for many years. Hyperoxaluria was present in all patients and decreased significantly when the drug was interrupted. Significant hyperoxaluria was also observed in volunteers after ingestion of piridoxilate (600 mg per day) or iv (200 mg). ...

Glyoxylic acid's use as a cleaning agent for a variety of industrial applications, as a speciality chemical and biodegradable copolymer feedstock(1) and as an ingredient in cosmetics(2) may result in its release to the environment through various waste streams(SRC).

Data specific to the biodegradation of glyoxylic acid in mixed cultures were not available, although glyoxylic acid was shown to biodegrade in one pure culture study(1). As a chemical class, the aliphatic acids have been shown to biodegrade readily in biodegradation screening studies(2-4); therefore, glyoxylic acid may biodegrade readily in the environment(SRC).

An estimated BCF of 3 was calculated for glyoxylic acid(SRC), using an estimated log Kow of -1.4(SRC) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for glyoxylic acid is estimated as 3X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that glyoxylic acid is not expected to volatilize from moist soil or water surfaces(2). The pKa of glyoxylic acid is 3.3(3), indicating that this compound will exist primarily in the ionized form in water and moist soils and the anionic form of glyoxylic acid will not volatilize(SRC). Glyoxylic acid may volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 1 mm Hg at 25 °C(SRC), determined from a fragment constant estimation method(4).

GLYOXALIC ACID DECR OXYGEN CONSUMPTION BY PREPARATIONS OF RAT HEART SARCOSOMES & THIS EFFECT WAS ASSOC WITH DEPRESSION IN STAGE 3 RESPIRATION.

THE INHIBITION OF STAGE 3 RESPIRATION BY MITOCHONDRIA IN VITRO BY GLYOXALATE DOES NOT SET IN IMMEDIATELY, CAN BE REVERSED IN PART BY THE ADDITION OF UNCOUPLING AGENT OR A DITHIOL, IS NON-COMPETITIVE AGAINST SUCCINATE, & CAN BE DEMONSTRATED WITH SUBSTRATES REQUIRING THE INVOLVEMENT OF OTHER MEMBRANE TRANSPORT SYSTEMS.

GLYOXYLIC ACID WAS NONMUTAGENIC IN SALMONELLA TYPHIMURIUM STRAINS TA98 & 100.

The renal pathology /was studied/ in a series of rats given ethylene glycol or its metabolites, including glyoxylic acid. In animals given single large doses of ethylene glycol (9 to 12 g/kg), striking oxalate formation was present in renal tubules. Crystals appeared throughout the proximal and distal convoluted tubules and were less numerous in the collecting tubules. In only one rat, oxalate crystals were present in the brain, as has also been reported in human poisoning. Oxalate crystals were also present in renal tubules of animals receiving glycol aldehyde, glycolic acid, and glyoxylic acid, although the renal oxalosis was less extensive with glycolaldehyde. The three proposed metabolites were all more toxic on an acute basis than was ethylene glycol since a number of animals died within eight hours of receiving 5 to 6 g/kg of body weight of the metabolites. Renal tubular pathology was not always accompanied by crystal formation, and the author concludes that cytotoxicity, rather than simple mechanical obstruction, is largely responsible for renal failure.

For more Non-Human Toxicity Excerpts (Complete) data for GLYOXYLIC ACID (7 total), please visit the HSDB record page.

The rate constant for the vapor-phase reaction of glyoxylic acid with photochemically-produced hydroxyl radicals has been estimated as 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 29 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Glyoxylic acid has an absorption maxima of 351 nm in 60% acetonitrile/water solution(2) which indicates a potential for direct photolysis in the environment(SRC). Glyoxylic acid undergoes rapid direct photolysis in the vapor-phase(3); the atmospheric daytime persistence of glyoxylic acid is not expected to exceed a few hours(3). A pKa of 3.3(4), indicates that glyoxylic acid will primarily exist in the ionized form in the environment.