HCID 86725410, 화합물 → HCID 86725411, 화합물
반응식
[F:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([N+:10]([O-])=O)[CH:5]=[C:4]([F:13])[C:3]=1[N:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1>CO.[Ni]>[NH2:10][C:6]1[CH:5]=[C:4]([F:13])[C:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:25])([CH3:26])[CH3:24])=[O:21])[CH2:18][CH2:19]2)=[C:2]([F:1])[C:7]=1[O:8][CH3:9]참가 물질
4
실험 절차
To a solution of the product of Example 52B (600 mg, 1.6 mmol) in methanol (100 mL) was added Raney Nickel (60 mg) and the mixture was stirred under hydrogen for 14 hours. The catalyst was filtered off and the filtrate was concentrated and purified by flash chromatography on silica gel (200-300 mesh) eluting with 100/1 dichloromethane/methanol to provide the title compound. MS: 344 (M+H+),
후처리
- filtrationThe catalyst was filtered off