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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Dimethylformamide → 3-({N-(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-N-[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)pyridine-2-carbonitrile

HRID 1504141
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인쇄 미리보기

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HRID 1504141 반응식
Cl[C:2]1[C:7]([CH2:8][N:9]([CH2:23][C:24]2[CH:41]=[CH:40][C:27]3[N:28]([CH2:38][CH3:39])[C:29](=[O:37])[C:30]([CH3:36])([CH3:35])[C:31](=[O:34])[N:32]([CH3:33])[C:26]=3[CH:25]=2)[CH2:10][CH2:11][N:12]2[CH:17]=[CH:16][C:15]3[O:18][C:19]([CH3:21])=[CH:20][C:14]=3[C:13]2=[O:22])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:42][N:43](C=O)C>[C-]#N.[Zn+2].[C-]#N.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(P(C2C=CC=CC=2)[C-]2C=CC=C2)C=CC=CC=1.[C-]1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=C1.[Fe+2].[Zn].O>[CH2:38]([N:28]1[C:29](=[O:37])[C:30]([CH3:36])([CH3:35])[C:31](=[O:34])[N:32]([CH3:33])[C:26]2[CH:25]=[C:24]([CH2:23][N:9]([CH2:8][C:7]3[C:2]([C:42]#[N:43])=[N:3][CH:4]=[CH:5][CH:6]=3)[CH2:10][CH2:11][N:12]3[CH:17]=[CH:16][C:15]4[O:18][C:19]([CH3:21])=[CH:20][C:14]=4[C:13]3=[O:22])[CH:41]=[CH:40][C:27]1=2)[CH3:39]
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참가 물질

8

반응물 2

HCID 6228DimethylformamideHCID 866704802-Chloro-3-({(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-[2-(2-methyl-4-oxo-4-H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)pyridine

생성물 1

HCID 706571733-({N-(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-N-[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)pyridine-2-carbonitrile

시약·촉매·용매 5

HCID 11186
Zinc cyanide (Zn(CN)2)
촉매
HCID 23994Zinc촉매
HCID 635956Ferrocene-1,1'-bis-(diphenylphosphine)촉매
HCID 9811564Bis(dibenzylideneacetone)palladium촉매
HCID 962Water용매

반응 조건

온도
95 °C

실험 절차

2-Chloro-3-({(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-[2-(2-methyl-4-oxo-4H-furo[3,2-c]pyridin-5-yl)ethyl]amino}methyl)pyridine (0.3 g), zinc cyanide(120 mg), tris(dibenzylideneacetone)dipalladium(24 mg), 1,1′-bis(diphenylphosphino)ferrocene(14 mg), and zinc powder(3.4 mg) were added to DMF(3 ml), and the mixture was heated at 95° C. for 3 hours. The reaction liquid was cooled to room temperature. Water was added to the reaction mixture and subjected to celite filtration. Extraction with ethyl acetate was performed. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate: methanol=93:7). The purified product was condensed under reduced pressure, and the residue was recrystallized from ether to give the title compound(1.35 g) as a white powder.

후처리

  1. customThe reaction liquid
  2. temperaturewas cooled to room temperature
  3. filtrationsubjected to celite filtration
  4. extractionExtraction with ethyl acetate
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (ethyl acetate: methanol=93:7)
  8. customcondensed under reduced pressure
  9. customthe residue was recrystallized from ether

출처 및 근거

ORD 기록
ord-32ad16512e7a4dfbb4159b1666a5e4d1
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09212187B2

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