Hydrazine hydrate (1:1) → 4-(2,3-dimethylphenoxy)aniline

HRID 1505357노트

반응식

HRID 1505357 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:12]=2[CH3:18])=[CH:6][CH:5]=1)([O-])=O.O.NN>C(O)C.[Pd]>[CH3:18][C:12]1[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:11]=1[O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 6181291,2-Dimethyl-3-(4-nitrophenoxy)benzene2회

생성물 1

HCID 71392004-(2,3-dimethylphenoxy)aniline수율 105%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

2,3-dimethylphenyl 4-nitrophenyl ether (Intermediate 73, 865 mg) was dissolved in ethanol (10 mL) to give a pale yellow solution. Hydrazine hydrate 50% (0.698 mL, 7.1 mmol) and Pd/C (37.8 mg, 0.36 mmol) were added. The reaction mixture was stirred at 90° C. for 1 hour. The reaction mixture was filtered and the organic phase was evaporated under vacuum to afford the title compound as a pale yellow oil (796 mg).

후처리

  1. customto give a pale yellow solution
  2. filtrationThe reaction mixture was filtered
  3. customthe organic phase was evaporated under vacuum

출처 및 근거

ORD 기록
ord-a242059693db49dd9403348fc0f5d883
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216967B2

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