Hydrochloric Acid → HCID 178429734, 화합물
반응식
Cl.[F:2][C:3]1[C:8]([NH:9][C:10]2[C:15]([C:16]3[N:24]=[CH:23][N:22]=[C:21]4[C:17]=3[N:18]=[CH:19][N:20]4C3CCCCO3)=[CH:14][CH:13]=[CH:12][N:11]=2)=[C:7]([F:31])[CH:6]=[CH:5][C:4]=1[NH:32][S:33]([C:36]1[CH:40]=[C:39]([CH3:41])[O:38][C:37]=1[C:42]([F:45])([F:44])[F:43])(=[O:35])=[O:34]>>[N:24]1[C:16]([C:15]2[C:10]([NH:9][C:8]3[C:3]([F:2])=[C:4]([NH:32][S:33]([C:36]4[CH:40]=[C:39]([CH3:41])[O:38][C:37]=4[C:42]([F:45])([F:44])[F:43])(=[O:35])=[O:34])[CH:5]=[CH:6][C:7]=3[F:31])=[N:11][CH:12]=[CH:13][CH:14]=2)=[C:17]2[C:21]([NH:20][CH:19]=[N:18]2)=[N:22][CH:23]=1참가 물질
3
실험 절차
1M aqueous hydrochloric acid solution was added into the N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-5-methyl-2-(trifluoromethyl)furan-3-sulfonamide (12 mg, 0.020 mmol) prepared at Step 10 and stirred for 2 hours. After the reaction, the reactant was washed with an aqueous solution of sodium hydrogen carbonate and salt water. After extraction with ethylacetate, the organic layer was dried with sulfuric anhydride magnesium and vacuum concentrated, and then refined by means of column chromatography, so that 9 mg of the target compound, N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-5-methyl-2-(trifluoromethyl)furan-3-sulfonamide (percentage yield: 85%), was obtained.
후처리
- customprepared at Step 10
- customAfter the reaction
- washthe reactant was washed with an aqueous solution of sodium hydrogen carbonate and salt water
- extractionAfter extraction with ethylacetate
- dry with materialthe organic layer was dried with sulfuric anhydride magnesium and vacuum
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-6c02e65179254fe4a9e3d34c45727fa3
- 출처 데이터셋
- uspto-grants-2015_12
- 특허 번호
- US09216981B2
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