Methyl 1-benzyl-4-methylpiperidin-3-yl-carbamate → 1-Benzyl-4-methylpiperidin-3-amine

HRID 1506191노트

반응식

HRID 1506191 반응식
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH3:14])[CH:10]([NH:15]C(=O)OC)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH3:14])[CH:10]([NH2:15])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 53396489Methyl 1-benzyl-4-methylpiperidin-3-yl-carbamate

생성물 1

HCID 545937521-Benzyl-4-methylpiperidin-3-amine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Crude methyl rac-(3R,4R)-1-benzyl-4-methylpiperidin-3-ylcarbamate (2.3 g) in concentrated hydrochloric acid (15 mL) was refluxed for one day under heating and allowed to cool to room temperature. The hydrochloric acid was removed under reduced pressure, and the reaction mixture was partitioned between chloroform and saturated aqueous sodium chloride. The aqueous layer was basified with saturated aqueous sodium carbonate and extracted with ethyl acetate twice, and the organic layers were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting brown oil (4.94 g) containing the title compound was used for the next step without further purification.

후처리

  1. temperatureunder heating
  2. customThe hydrochloric acid was removed under reduced pressure
  3. customthe reaction mixture was partitioned between chloroform and saturated aqueous sodium chloride
  4. extractionextracted with ethyl acetate twice
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. additionThe resulting brown oil (4.94 g) containing the title compound
  8. customwas used for the next step without further purification

출처 및 근거

ORD 기록
ord-589fcfe46d5b4d5090fc4ce70ae4beee
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216999B2

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