Ethyl orthoformate → HCID 86726636, 화합물

HRID 1506215노트

반응식

HRID 1506215 반응식
[CH:1]1([NH:7][C:8]2[C:13]([C:14]([NH2:16])=[O:15])=[CH:12][N:11]=[C:10]3[N:17]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[CH:18]=[CH:19][C:9]=23)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:28](OCC)(OCC)[O:29]CC>>[CH:1]1([NH:7][C:8]2[C:13]([C:14]([NH:16][CH:28]=[O:29])=[O:15])=[CH:12][N:11]=[C:10]3[N:17]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[CH:18]=[CH:19][C:9]=23)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 31214Ethyl orthoformateHCID 71258449HCID 71258449, 화합물

생성물 1

HCID 86726636HCID 86726636, 화합물수율 27%

실험 절차

4-(Cyclohexylamino)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide (45 mg, 0.12 mmol) in triethyl orthoformate (2 mL) was stirred at 120° C. for one day. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1→0/1 (v/v)) to give the title compound as a pale yellow amorphous (12.4 mg, yield 27%).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1→0/1 (v/v))

출처 및 근거

ORD 기록
ord-8fe5eb55c18a40ada8e691177651a5c7
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09216999B2

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