홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

3-(1-(4-Fluorophenyl)cyclohexyl)propanoyl chloride → 2-(2-(1-(4-Fluorophenyl)cyclohexyl)ethyl)-7-vinyl-4,5-dihydronaphtho[1,2-d]oxazole

HRID 1506382
노트
인쇄 미리보기

반응식

HRID 1506382 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:14][CH2:15][C:16](Cl)=[O:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH:19]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)/[C:27](=[N:31]/O)/[CH2:26][CH2:25][CH2:24]2)=[CH2:20]>ClC1C=CC=CC=1Cl.CN(C)C1C=CN=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:14][CH2:15][C:16]3[O:17][C:26]4[CH2:25][CH2:24][C:23]5[C:28](=[CH:29][CH:30]=[C:21]([CH:19]=[CH2:20])[CH:22]=5)[C:27]=4[N:31]=3)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 866698893-(1-(4-Fluorophenyl)cyclohexyl)propanoyl chlorideHCID 121012766(NE)-N-(6-ethenyl-3,4-dihydro-2H-naphthalen-1-ylidene)hydroxylamine2회

생성물 1

HCID 671707562-(2-(1-(4-Fluorophenyl)cyclohexyl)ethyl)-7-vinyl-4,5-dihydronaphtho[1,2-d]oxazole수율 14.7%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매
HCID 7239
1,2-Dichlorobenzene
용매

실험 절차

To a solution of 3-(1-(4-fluorophenyl)cyclohexyl)propanoyl chloride (Preparation 42B, 215 mg, 0.799 mmol) and 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime (Intermediate 1, 224 mg, 1.199 mmol) in 1,2-dichlorobenzene (2 mL) was added 4-(dimethylamino)pyridine (6.15 mg, 0.050 mmol), and the mixture was microwaved at 180° C. for 10 mins. The mixture of was purified by Combiflash (silica gel, 24 g) eluting with 5:95 followed by 2:8 ethyl acetate-hexane to give the desired 2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-7-vinyl-4,5-dihydronaphtho[1,2-d]oxazole (47 mg, 14.6% yield) as an oil. LC/MS M+1=402.26.

후처리

  1. customthe mixture was microwaved at 180° C. for 10 mins
  2. additionThe mixture
  3. customof was purified by Combiflash (silica gel, 24 g)
  4. washeluting with 5:95

출처 및 근거

ORD 기록
ord-68ab1e70827d4d1899b704b580895c2c
출처 데이터셋
uspto-grants-2015_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09216972B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트