Kinetin → HCID 14035908, 화합물

HRID 1506568

반응식

HRID 1506568 반응식
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[N:16]=[CH:15][N:14]=[C:10]3[N:11]=[CH:12][NH:13][C:9]=23)[O:4][CH:5]=1.Br[CH2:18][CH2:19][Cl:20].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[CH2:6]([NH:7][C:8]1[N:16]=[CH:15][N:14]=[C:10]2[C:9]=1[N:13]=[CH:12][N:11]2[CH2:18][CH2:19][Cl:20])[C:3]1[O:4][CH:5]=[CH:1][CH:2]=1

참가 물질

5

반응물 3

HCID 3830KinetinHCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium Carbonate

생성물 1

HCID 14035908HCID 14035908, 화합물수율 80%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Kinetin (2 g, 9.3 mmol), 1-bromo-2-chloroethane (1.3 g, 9.1 mmol) and K2CO3 (2.5 g, 24 mmol) were mixed in 100 ml dimethylsulfoxide (DMSO) for 18 h. The reaction mixture was poured onto 200 ml drift ice and then extracted in ethyl acetate and dried over Na2SO4. The ethyl acetate layer was evaporated in vacuo. The pure product of white powder character was recrystallised from methanol. Yield: 80%. 1H NMR (DMSO-d6): 4.07 (2H, t, J=5.82), 4.52 (2H, t, J=5.82), 4.70 (2H, s (br)), 6.23 (1H, d, J=2.67), 6.35 (1H, m), 7.53 (1H, d, J=2.67), 8.22 (2H, m), 8.25 (1H, s)

후처리

  1. additionThe reaction mixture was poured onto 200 ml
  2. extractionextracted in ethyl acetate
  3. dry with materialdried over Na2SO4
  4. customThe ethyl acetate layer was evaporated in vacuo
  5. customThe pure product of white powder character was recrystallised from methanol

출처 및 근거

ORD 기록
ord-c18c315c182e4ba582e80e42200137a9
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09220269B2

연결된 노트

불러오는 중…