Hydrogen Bromide → 5-Bromo-3-Methylpentanoic Acid

HRID 1506614

반응식

HRID 1506614 반응식
[CH3:1][CH:2]1[CH2:8][CH2:7][O:6][C:4](=[O:5])[CH2:3]1.[BrH:9]>ClCCl>[Br:9][CH2:7][CH2:8][CH:2]([CH3:1])[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 79142beta-Methyl-delta-valerolactone

생성물 1

HCID 211819805-Bromo-3-Methylpentanoic Acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of β-methyl-δ-valerolactone (3.0 g) in anhydrous dichloromethane (30 ml), cooled to 0-5° C., was saturated with hydrogen bromide gas and the mixture was stirred for three days at room temperature. The mixture was diluted with dichloromethane (100 ml) and the resulting solution was washed with 10-% NaCl (3×30 ml). Next the solution was dried with anhydrous MgSO4 and the solvent was distilled under reduced pressure, Yield: 4.6 g. NMR ˜100% pure product.

후처리

  1. washthe resulting solution was washed with 10-% NaCl (3×30 ml)
  2. dry with materialNext the solution was dried with anhydrous MgSO4
  3. distillationthe solvent was distilled under reduced pressure, Yield: 4.6 g

출처 및 근거

ORD 기록
ord-0fffdb26341f467086ab220ecc0b09d0
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09220790B2

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