Sodium Hydroxide → 3-(Pyridin-2-yl)benzoic acid

HRID 1507036노트

반응식

HRID 1507036 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12]C)=[O:11].[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([OH:12])=[O:11]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 3364101Methyl 3-(pyridin-2-yl)benzoate

생성물 1

HCID 51525923-(Pyridin-2-yl)benzoic acid수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl 3-(pyridin-2-yl)benzoate (400 mg, 1.88 mmol) in MeOH (3 mL) was added aqueous of NaOH (1 mL, 40 mol %). The reaction mixture was stirred at room temperature for 3 h and concentrated. The crude residue was dissolved in water and the pH was adjusted to 5˜6 with 2N of HCl. The solution was extracted with ethyl acetate, brine, dried over sodium sulfate, filtered and concentrated. (350 mg, yield 93%) MS (ESI+) e/z: 200.1 [M+1]+.

후처리

  1. concentrationconcentrated
  2. dissolutionThe crude residue was dissolved in water
  3. extractionThe solution was extracted with ethyl acetate, brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a89da6cea659468590adb1164a31b108
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221794B2

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