Hydrochloric Acid → HCID 178517540, 화합물

HRID 1507504

반응식

HRID 1507504 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:11]([Cl:30])=[N:12][C:13]([CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[N:14][C:15]=1[OH:16].Cl>CO>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:15]([OH:16])=[N:14][C:13]([CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[N:12][C:11]=1[Cl:30]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178451808HCID 178451808, 화합물

생성물 1

HCID 178517540HCID 178517540, 화합물수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Into a solution of tert-butyl 4-[5-(1,3-benzothiazol-2-yl)-4-chloro-6-hydroxypyrimidin-2-yl]piperidine-1-carboxylate (44.7 g, 100.01 mmol, 1.00 equiv) in methanol (50 ml) was added concentrated hydrochloric acid (50 mL, 12 M). The resulting solution was stirred for 30 min at room temperature. Concentration under vacuum gave 34 g of 5-(1,3-benzothiazol-2-yl)-6-chloro-2-(piperidin-4-yl)pyrimidin-4-ol as a yellow solid, which was used directly for next step without further purification. MS m/z [M+H](ESI): 347.

후처리

  1. concentrationConcentration under vacuum

출처 및 근거

ORD 기록
ord-bd1135f847474bb9bc2305e9ca91e855
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221809B2

연결된 노트

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