Nicotinic Acid → N-(1-Ethyl-3,3-dimethyl-2-oxoindolin-6-yl)nicotinamide

반응식

[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:15])([CH3:14])[C:7](=[O:13])[N:8]2[CH2:11][CH3:12])=[CH:4][CH:3]=1.[C:16](O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=1>>[CH2:11]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([NH:1][C:16](=[O:23])[C:17]3[CH:22]=[CH:21][CH:20]=[N:19][CH:18]=3)[CH:10]=2)[C:6]([CH3:14])([CH3:15])[C:7]1=[O:13])[CH3:12]

참가 물질

반응물 2

HCID 938Nicotinic Acid

HCID 69068988HCID 69068988, 화합물2회

생성물 1

HCID 73425721N-(1-Ethyl-3,3-dimethyl-2-oxoindolin-6-yl)nicotinamide

실험 절차

Prepared in analogy to example 17 from 6-amino-1-ethyl-3,3-dimethylindolin-2-one (G. Georges et al., US2006/142247 A1) and nicotinic acid. The title compound was obtained as white solid.

출처 및 근거

ORD 기록: ord-c2e1d05e27114afdaef6ec3b7cbd3fc8
출처 데이터셋: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09221816B2

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