Ethyl 3-hydroxyfuro[2,3-c]pyridine-2-carboxylate → Furo[2,3-C]pyridin-3(2H)-one

HRID 1508198노트

반응식

HRID 1508198 반응식
C(OC([C:6]1[O:14][C:9]2=[CH:10][N:11]=[CH:12][CH:13]=[C:8]2[C:7]=1[OH:15])=O)C>Cl.O>[O:14]1[C:9]2=[CH:10][N:11]=[CH:12][CH:13]=[C:8]2[C:7](=[O:15])[CH2:6]1

참가 물질

4

반응물 1

HCID 54723934Ethyl 3-hydroxyfuro[2,3-c]pyridine-2-carboxylate

생성물 1

HCID 14199080Furo[2,3-C]pyridin-3(2H)-one

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

A suspension of 3-hydroxyfuro[2,3-c]pyridine-2-carboxylic acid ethyl ester (10 mmol) in 10 mL 25% HCl solution and 5 mL H2O was heated to reflux overnight. After cooling to RT, the reaction mixture was quenched with sat. aq. NaHCO3 solution and extracted with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to give the desired product as brown solid;

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customthe reaction mixture was quenched with sat. aq. NaHCO3 solution
  4. extractionextracted with EtOAc
  5. dry with materialThe combined organic layers were dried over MgSO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e8465752acde40e68505e484cd7c1730
출처 데이터셋
uspto-grants-2015_12
특허 번호
US09221832B2

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