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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Sodium Hydroxide → (3S)-1-(2-fluoroethyl)-3-hydroxypyrrolidine

HRID 15083
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HRID 15083 반응식
[OH-].[Na+].[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([O:11]C(=O)C)[CH2:7]1>CO>[F:3][CH2:4][CH2:5][N:6]1[CH2:10][CH2:9][C@H:8]([OH:11])[CH2:7]1
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참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86614898HCID 86614898, 화합물

생성물 1

HCID 80609424(3S)-1-(2-fluoroethyl)-3-hydroxypyrrolidine수율 35.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4N aqueous sodium hydroxide solution (2 mL) was added to methanol (10 mL) solution of (3S)-1-(2-fluoroethyl)-3-acetoxypyrrolidine (507 mg, 2.89 mmols), and stirred at room temperature for an hour. The reaction liquid was concentrated under reduced pressure, extracted with chloroform and dried over anhydrous sodium sulfate. Concentrating the reaction liquid under reduced pressure, the title compound (135 mg, 35%) was obtained.

후처리

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. extractionextracted with chloroform
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationConcentrating
  6. customthe reaction liquid under reduced pressure

출처 및 근거

ORD 기록
ord-760412e2ac6c4faea17af6eff13e4d41
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07732456B2

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